中文簡(jiǎn)介

甾體生物化學(xué)和分子生物學(xué)雜志致力于甾體相關(guān)領(lǐng)域的新的實(shí)驗(yàn)或理論發(fā)展。它出版原始論文以及一般和小型評(píng)論、選定會(huì)議的記錄和快速通訊(特別感興趣的高度專題的簡(jiǎn)要文章)。該雜志涵蓋了廣泛的主題有關(guān)類固醇:分子，細(xì)胞，和生理活動(dòng)的類固醇激素，類固醇抗激素及其類似物通過調(diào)控基因表達(dá)或其他機(jī)制。甾體-甲狀腺-維甲酸超家族受體的結(jié)構(gòu)、功能、調(diào)控及細(xì)胞生物學(xué)。甾體、甾體受體及其他信號(hào)轉(zhuǎn)導(dǎo)途徑的交叉對(duì)話。類固醇與細(xì)胞增殖，調(diào)節(jié)細(xì)胞周期基因。類固醇運(yùn)輸。類固醇與癌癥:類固醇激素與細(xì)胞因子、生長(zhǎng)因子、生長(zhǎng)抑制因子及癌基因在正常及腫瘤組織中的功能關(guān)系。類固醇和癌癥預(yù)防。類固醇和生物相關(guān)化合物的生物合成、分泌和代謝，以及它們受肽激素、前列腺素和其他物質(zhì)的調(diào)節(jié)。參與類固醇生成的酶的分子方面。新型類固醇激動(dòng)劑或拮抗劑的新治療應(yīng)用。類固醇和神經(jīng)內(nèi)分泌學(xué)或神經(jīng)免疫學(xué)。神經(jīng)甾體，甾體對(duì)合乳酸傳遞和調(diào)節(jié)的作用。類固醇激素和高血壓。類固醇及其對(duì)骨骼和心血管系統(tǒng)的作用。類固醇酶抑制劑。更年期類固醇和類似物。激素替代療法中的類固醇。類固醇激素在骨質(zhì)疏松癥:基礎(chǔ)和臨床應(yīng)用。類固醇和避孕。類固醇代謝缺陷。類固醇激素在懷孕期間，發(fā)育和性別分化。天然和合成類固醇及其相關(guān)生物活性化合物的結(jié)構(gòu)、理化、化學(xué)和藥理特性。類固醇和生物相關(guān)物質(zhì)的創(chuàng)新技術(shù)。類固醇及其受體的生物合成、代謝或作用的先天或后天變化的臨床和生理學(xué)研究。比較內(nèi)分泌學(xué)和類固醇的進(jìn)化。環(huán)境對(duì)類固醇代謝和作用的影響。

　　英文簡(jiǎn)介

The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental or theoretical developments in areas related to steroids. It publishes original papers as well as general and mini-reviews, proceedings of selected meetings and rapid communications (brief highly-topical articles of particular interest).The journal covers a wide range of topics relating to steroids:- Molecular, cellular, and physiological actions of steroid hormones, steroid anti-hormones and their analogs via regulation of gene expression or other mechanisms. Structure, function, regulation, and cell biology of receptors of the steroid-thyroid-retinoid superfamily. Cross-talk between steroids, steroid receptors and other signal transduction pathways. Steroids and cell proliferation, regulation of cell cycle genes. Steroid transport. Steroids and cancer: functional relationships in normal and neoplastic tissues between steroid hormones and cytokines, growth factors, growth inhibitors, and oncogenes. Steroids and cancer prevention. Biosynthesis, secretion, and metabolism of steroids and of biologically-related compounds, and their regulation by peptide hormones, prostaglandins and other substances. Molecular aspects of enzymes involved in steroidogenesis. Novel therapeutic applications of new steroid agonists or antagonists. Steroids and neuroendocrinology or neuroimmunology. Neurosteroids, steroid action on synactic transmission and modulation. Steroid hormones and hypertension. Steroids and their actions on bone and on the cardiovascular systems. Steroid enzyme inhibitors. Steroids and analogs in menopause. Steroids in hormone replacement therapy. Steroid hormones in osteoporosis: basic and clinical applications. Steroids and contraception. Defects in steroid metabolism. Steroid hormones during pregnancy, development and sex differentiation. Structure, physicochemical, chemical and pharmacological characteristics of natural and synthetic steroids and related compounds of biological interest. Innovative techniques relating to steroids and biologically-related substances. Clinical and physiological studies of inborn or acquired changes of biosynthesis, metabolism or action of steroids and their receptors. Comparative endocrinology and evolution of steroids. Environmental effects on steroid metabolism and action.

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