中文簡介

生命科學工程(ELS)關注生命科學和生物技術的工程原理和創新。ELS涵蓋的生命科學和生物技術包括利用生物分子(例如蛋白質/酶)和細胞(微生物、植物和哺乳動物起源)進行生物合成、生物轉化、基于細胞的治療和基于生物的解決方案，用于工業和制藥生物技術以及生物醫學。ELS特別旨在促進生物學家、生物技術專家和工程師之間的跨學科合作，以便對不同應用領域的生物部件和過程進行定量理解和整體工程(設計-構建測試)。應用這種工程思維，ELS處理科學問題和技術，例如:?生物合成和生物轉化的工程電子傳遞(例如通過光電生物技術)?為生物分子工程(如DNA/基因組、RNA和蛋白質)和生物生產底盤開發定量工具?獲取新的生物分子和生物材料(如蛋白質、天然和芳香化合物、精細化學品和構建塊)?工程代謝途徑及其調控(例如在代謝工程和合成生物學的背景下)?闡明細胞調控和細胞間相互作用(如微生物組、共培養、干細胞和組織)?工程新型生物反應器和生物工藝(例如用于生產生物制藥、精細化學品、大宗商品和生物燃料，包括廢物流和替代原料的使用)因此，ELS雜志涵蓋了現代生物化學工程和生物技術的所有領域，包括生物分子、生物過程、代謝和生物系統工程。預計手稿將涉及不同分子和工藝水平的工程原理和創新與指示數字或性能參數。用于這些目的的創新方法和工具也屬于ELS的范圍。

　　英文簡介

Engineering in Life Sciences (ELS) focuses on engineering principles and innovations in life sciences and biotechnology. Life sciences and biotechnology covered in ELS encompass the use of biomolecules (e.g. proteins/enzymes) and cells (microbial, plant and mammalian origins) for biosynthesis, biotransformation, cell-based treatment and bio-based solutions in industrial and pharmaceutical biotechnologies as well as in biomedicine. ELS especially aims to promote interdisciplinary collaborations among biologists, biotechnologists and engineers for quantitative understanding and holistic engineering (design-built-test) of biological parts and processes in the different application areas. Applying this engineering mindset, ELS addresses scientific questions and technologies, for example, regarding:? Engineering electron transfer for biosynthesis and biotransformation (e.g. via photo- and electrobiotechnology)? Developing quantitative tools for engineering of biomolecules (e.g. DNA/genome, RNA and proteins) and bioproduction chassis? Accessing novel biomolecules and biomaterials (e.g. proteins, natural and aroma compounds, fine chemicals and building blocks)? Engineering metabolic pathways and their regulation (e.g. in the context of metabolic engineering and synthetic biology)? Unravelling cellular regulation and cell-to-cell interactions (e.g. microbiome, co-cultures, stem cells and tissues)? Engineering novel bioreactors and bioprocesses (e.g. for the production of biopharmaceuticals, fine chemicals, commodities and biofuels, including use of waste streams and alternative feedstock)As such, the journal ELS covers the whole range of modern biochemical engineering and biotechnology comprising biomolecule, bioprocess, metabolic and biosystems engineering. Manuscripts are expected to address the engineering principles and innovations at different molecular and process levels with indicative numbers or performance parameters. Innovative methods and tools for these purposes are also within the scope of ELS.

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