中文簡介

疾病模型與機制（DMM）發(fā)布了最初的研究、資源和邀請評論，重點是使用模型系統(tǒng)更好地理解、診斷和治療人類疾病。DMM的主要目的是通過促進基礎研究人員和臨床研究人員在轉化科學方面的合作來促進人類健康。該雜志致力于提出符合這一目標的非常重要的研究。DMM的跨學科性質意味著各種各樣的疾病、方法和模型都在其范圍內(nèi)。DMM內(nèi)容示例：顯著促進我們對人類疾病機制、診斷或治療的理解的基礎研究，具有廣泛的相關性。使用模型系統(tǒng)的候選療法的藥物篩選和臨床前分析介紹經(jīng)過徹底驗證的新模型，以證明其在疾病研究中的實用性。*為疾病和/或示范社區(qū)提供廣泛有用工具的新方法和資源針對生物醫(yī)學科學中當前和新興主題的全面、專家評論和海報翻譯研究領域的主要科學家訪談討論更廣泛的社會關注問題的社論，包括監(jiān)管、倫理和政策問題整理與特定病區(qū)或模式系統(tǒng)有關的文章的特別收藏*一般不考慮出版說明性的工作，例如說明一個示范系統(tǒng)的特點，而不表明其對促進某一領域的作用，除非編輯小組考慮到新的模式本身，以便更好地了解疾病的機制和(或)證明對評價治療方法有明確的用處。感興趣的模型系統(tǒng)包括：脊椎動物，如小鼠、斑馬魚、青蛙、大鼠和其他哺乳動物無脊椎動物，如黑腹果蠅和秀麗隱桿線蟲獨特的體外或體外模型，如基于干細胞的模型、基于患者材料的器官和系統(tǒng)微生物，如酵母和盤基網(wǎng)柄菌其他與人類疾病研究有關的生物系統(tǒng)感興趣的疾病領域包括：癌癥神經(jīng)退行性疾病和神經(jīng)系統(tǒng)疾病精神疾病代謝紊亂，包括糖尿病和肥胖心血管疾病、中風和高血壓胃腸道疾病傳染病自身免疫和炎癥發(fā)育性疾病肌肉骨骼疾病腎臟或肝臟疾病眼部疾病藥物和生物標志物的發(fā)現(xiàn)/篩選再生醫(yī)學中的干細胞療法

　　英文簡介

Disease Models & Mechanisms (DMM) publishes original research, resources and invited reviews that focus on the use of model systems to better understand, diagnose and treat human disease. The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting highly significant research that meets this goal. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its scope.Examples of DMM content:Basic research that significantly advances our understanding of human disease mechanisms, diagnosis or treatment, and is of broad relevanceDrug screens and preclinical analyses of candidate therapies using model systemsPresentation of new models that have been thoroughly validated to demonstrate their utility in disease studies* New methods and resources that provide broadly useful tools for a disease and/or model communityComprehensive, expert reviews and posters addressing current and emerging themes in biomedical scienceInterviews with leading scientists in translational researchEditorials that discuss wider issues of interest to the community, including regulatory, ethical and policy issuesSpecial collections that collate articles relating to a particular disease area or model system *Descriptive work, such as the characterisation of a model system without demonstration of its usefulness to advance a field, is generally not considered for publication, unless the new model itself is considered by the Editorial team to provide an improved understanding of the disease mechanism and/or to demonstrate clear usefulness for the evaluation of treatment approaches. Model systems of interest include:Vertebrates such as mice, zebrafish, frogs, rats and other mammalsInvertebrates such as Drosophila melanogaster and Caenorhabditis elegans Unique in vitro or ex vivo models, such as stem-cell-based models, organoids and systems based on patient materialMicroorganisms such as yeast and DictyosteliumOther biological systems with relevance to human disease researchDisease areas of interest include:CancerNeurodegenerative and neurological diseasesPsychiatric disordersMetabolic disorders, including diabetes and obesityCardiovascular diseases, stroke and hypertensionGastrointestinal diseasesInfectious diseasesAutoimmunity and inflammationDevelopmental diseasesMusculoskeletal disordersRenal or liver diseaseEye disordersDrug and biomarker discovery/screeningStem cells therapies in regenerative medicine

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